Current Issue : January-March Volume : 2012 Issue Number : 1 Articles : 4 Articles
With the suitable modifications in the structure 1,4-dihydropyrazol-5-one a five membered heterocycle has been found with enormous biological activities. The present review is an attempt made to direct the attention of the researchers towards the 1,4-dihydropyrazol-5-one moity for the development of newer chemical entities which will be quite useful in the treatment of various life threatening diseases and disorders. Along with the development in the various methods used for synthesis of 1,4-dihydropyrazol-5-one with profound biological activities one can proceed with newer area of Medicinal chemistry....
Quinoxaline incorporated Schiff bases (4a-j) were synthesized by the condensation of 2-[(3-methylquinoxalin-2-yl)oxy]acetohydrazide(3) with indole-3-carbaldehyde, furfuraldehyde, 5-(4-nitrophenyl)-2-furfuraldehyde and substituted benzaldehydes under conventional and microwave irradiation methods. The microwave method was found to be remarkably successful with higher yields, less reaction time and environmental friendly compared to conventional heating method. The chemical structures of the synthesized compounds have been confirmed by IR, 1H NMR and Mass spectral data. All the compounds have been evaluated for antitubercular and anti-inflammatory activities....
Vilsmeier-Haack reaction of substituted phenyl hydrazone derivatives (1a-j) afforded 1,3-substituted diphenyl-1H-pyrazole-4-carbaldehydes (2a-j). Compounds (2a-j) on condensation with malonic acid gave (2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl)acrylic acids (3a-j) which on reaction with thionyl chloride afforded acryloyl chlorides. The reaction of acryloyl chlorides with anthranilic acid gave 2-({(2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl)prop-2-enoyl}amino) benzoic acids (4a-j) in good yields. The structures of the newly synthesized compounds have been confirmed on the basis of physical and spectral data. Some of the synthesized compounds have shown significant anti-inflammatory activity....
Vilsmeier-Haack reaction of substituted phenyl hydrazone derivatives (1a-j) afforded 1, 3-substituted diphenyl-1H-pyrazole-4-carbaldehydes (2a-j). Compounds (2a-j) on condensation with malonic acid gave (2E)-3-(1, 3-substituted diphenyl-1H-pyrazol-4-yl) acrylic acids (3a-j) which on reaction with thionyl chloride afforded acryloyl chlorides. The reaction of acryloyl chlorides with anthranilic acid gave 2-({(2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl)prop-2-enoyl}amino) benzoic acids (4a-j) in good yields. The structures of the newly synthesized compounds have been confirmed on the basis of physical and spectral data. Some of the synthesized compounds have shown significant anti-inflammatory activity....
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